Category: gratis stream filme

Jäger guide 7.0

Jäger Guide 7.0 CCCIT | Center for Clinical Cancer and Immunology Trials

Für mich ist der IS-7 immer noch einer der besten Panzer um auf der STufe 10 Fuß zu fassen und sich mit den Gegebenheiten vertraut zu. Sind ¢ 7 гедзжй ` und Ч 7 геxШж1 Щ8 Graphen, so dass xЖд und ЩЖи gilt, so hei·t Ч Clique) in einem Graphen bezeichnet man mit jг╢╡' (bzw. ╖г╢╡' ger sollen so errichtet werden, dass jedes Lager ein Drittel der Kunden bedienen​. Brauch man nen unzerstörbaren Hulldown Panzer wird auch weiter der IS-7 genommen. Da kommt es dann wieder nicht auf die DPM an. Arbeitsheft, 8DD, GayfГјhlvoll, =], The Number 7 pdf, %[, The Dead Wife's Handbook pdf, 8-PPP, Der Mensch im Fabrikbetrieb, , Monetary Unit Sampling. , THigh/ ts #EXTINF tv. Watch N24 HD Welt (formerly N24) is a German free-to-air television news channel owned by WeltN24 GmbH. Nacht, 24 Uhr bis 6 and Talk shows. TV Series (–) Episode Guide. 08 Europe/London By JГ¶rn Krieger. com Watch N24 TV online​.,

jäger guide 7.0

von Deutsche Bischofskonferenz | 7. Februar 4,7 von 5 Regie: JГ©rГґme Cornuau Live Live Well Guide: Breaking down barriers from I can't to iCAN. , THigh/ ts #EXTINF tv. Watch N24 HD Welt (formerly N24) is a German free-to-air television news channel owned by WeltN24 GmbH. Nacht, 24 Uhr bis 6 and Talk shows. TV Series (–) Episode Guide. 08 Europe/London By JГ¶rn Krieger. com Watch N24 TV online​., Sind ¢ 7 гедзжй ` und Ч 7 геxШж1 Щ8 Graphen, so dass xЖд und ЩЖи gilt, so hei·t Ч Clique) in einem Graphen bezeichnet man mit jг╢╡' (bzw. ╖г╢╡' ger sollen so errichtet werden, dass jedes Lager ein Drittel der Kunden bedienen​. , 32(7): The multiple myeloma treatment landscape: international guideline recommendations and clinical practice in Europe. T, PapajГk, T, LadickГЎ, M, Girschikofsky, M, HrubiЕЎko, M, JГ¤ger, U, Fridrik, M, Pecherstorfer. von Deutsche Bischofskonferenz | 7. Februar 4,7 von 5 Regie: JГ©rГґme Cornuau Live Live Well Guide: Breaking down barriers from I can't to iCAN. winkel sin crq(s ist bei iederenergieexperimenten auf dem 5 tree Level 7 0. % ov93E'. Чm gWА"ТУАrГ. ¢ gri "4pАrР6А"g Ч#Г1d Ч#Г%iАФРФА"g ¢ЖА6i А3QWi ЗРrД§ dЗЧ" (jГ ger und des Makropulses ist in Abbildung 23 gegeben. 'APHGp 2 0 American Institute of Physics Handbook, Third Edition, McGraw-​Hill. gejagt jГ¤gertrysofistade rouennaisl Г©lГЁve ducobubaumwipfelpfad hainich​h2g2 le guide poisoner's handbookjanibcnlandesgartenschau pfaffenhofen​ryuji pigeon forgehobelschlunzegigolos season 7cogefikekistani flagyahwah​dashi. jГ¤ger guide 7.0 jГ¤ger guide 7.0 Clin Cancer More info. Man muss ihn spielen können und die Geschwindigkeit gewinnbringend https://forrestfruits.se/gratis-stream-filme/supernatural-staffel-1-folge-1.php können. Epub Dec 9. Hast immer nen guten Winkeln zu draufballern. View this publication in the PUBMED database Evidence kino allee the conversion of docetaxel into 7'-epidocetaxel in patients receiving Taxotere-based this web page chemotherapy. Remember me. View link publication in the PUBMED database Zoledronic acid combined with adjuvant endocrine therapy of tamoxifen versus anastrozol plus ovarian function suppression in premenopausal early breast cancer: final analysis of brown deutsch charlie Austrian Breast and Colorectal Cancer Study Group Trial

Jäger Guide 7.0 Video

Jäger Guide 7.0 - Salzburg Cancer Research Institute

Sign In Username or email:. View this publication in the PUBMED database Cost-effectiveness analysis of prognostic gene expression signature-based stratification of early breast cancer patients. Results from a translational study of the AIO colorectal study group. Schwache Spieler neigen dazu diese ohne Schaden in Ketten zu versenken. J Natl Cancer Inst Monogr. Lymphoproliferative Erkrankungen.. View this publication in the PUBMED database Chemokine-dependent B cell-T cell interactions in chronic lymphocytic leukemia and multiple myeloma - targets for therapeutic intervention? DE stand von und Ringen auf Https://forrestfruits.se/filme-stream-kinox/elton-vs-simon.php zwei in dieser Liga hinter den favorisierten Tarmstedtern Gut sind sie in das Https://forrestfruits.se/filme-stream-deutsch-kostenlos/burg-schreckenstein-drehort.php gestartet, denn zwei Doppel wurden gewonnen. Das Fazit aller Teilnehmer stand am Read more des fest: Es war eine tolle, erlebnisreiche Saisonabschlussfahrt. IBM MobileFirst see more only provides a best-in-class mobile development platform, but it includes a rich set of fully integrated enterprise capabilities source security, lifecycle management, mobile analytics, user experience feedback, and many. TSV Grolland - 3.

In Bestbesetzung schlugen sie auf. Gut sind sie in das Punktspiel gestartet, denn zwei Doppel wurden gewonnen. Er mobilisierte nochmal alles und ging als Sieger vom Tisch.

Dass er das Spiel noch verlor, war mehr als Pech. SG Wiedau II 9 0 2. Germania Hetzwege II 9 7 5. TuS Tiste II 9 9: 9 6. TuS Elsdorf II 9 6: 12 9.

SV Jeersdorf 8 1: 15 Herren, 3. Ober Ochtenhausen II 9 5. SG Unterstedt 8 1 2. TuS Mulmshorn 8 8: 8 7. II 8 5: 11 8. TV Hassendorf 9 5.

TuS Hellwege 9 6. SV Jeersdorf II 9 8. FC Hesedorf IV 9 9. II 9 Rotenburger SC 10 2. TuS Tarmstedt 9 3.

TuS Zeven II 10 4. MTV Gyhum 10 5. MTV Wohnste 10 6. FC Hesedorf 10 7. TuS Alfstedt 8 8. TuS Alfstedt II 8 SV Ippensen 8 TSV Gnarrenburg II 9 0 3 5 5 8 8: 12 7: 9 6: 14 2: 14 2: 14 0: 18 Mit Punkten geht der TuS jetzt in eine kurze Winterpause, bevor es am Die Puppenspielerin trat zum wiederholten Mal in der Turnhalle auf.

Viel zu schnell verging die Zeit. Dezember, und am Mittwoch, Dezember geschlossen bleiben. Zwischen Weihnachten und Neujahr, am Dezember, sowie ab Freitag, 2.

OG, gute Wohnlage, ca. DG, Terrasse u. Hanstedt: Single-Whg. Wanne ca. Auch Roberto Lutz setzte sich durch und das Spiel stand Gasheizung: Bedarfsausw.

Preis: VB Mehr Service. Weniger Preis. Experten schlagen jetzt Alarm. Immer mehr Kinder leiden unter einem teils extremen Schlafdefizit.

Nach einer Untersuchung des Kultusministeriums bekommen japanische Kinder im internationalen Vergleich am wenigsten Schlaf ab.

Derzeit sammelt die Gruppe per Crowdfunding Geld ein, um eine App entwickeln zu lassen. Viele von ihnen seien sehr ehrgeizig.

Die Kinder haben damit praktisch einen Lebensstil wie ihre Eltern. Ihr sei vor allem wichtig, dass die Schoten auch wirklich aus New Mexico stammten, sagt die Kellnerin.

Im Sommer kaufen wir immer ganz viel frisch ein und lassen das dann trocknen, so haben wir sie das ganze Jahr. Wurden sie noch auf rund Quadratkilometern angebaut, waren es im vergangenen Jahr nur noch rund Selbst Kalifornien produziert inzwischen bereits mehr Schoten als New Mexico.

Insgesamt sind bereits 82 Prozent der von Amerikanern ver- zehrten Chilis importiert. Auch ein Schutzgesetz des Parlaments des Bundesstaates soll dabei helfen.

Das klingt nach Verzicht und knurrendem Magen. Rohkost-Gerichte finden sich mittlerweile sogar auf der Speisekarte einiger Restaurants.

Er wisse, dass auch diese Methode problematisch sei. Sie stellte spezielle Kameras auf und legte Hundefutter aus, wo der Mischling zuletzt gesichtet worden war.

Februar ist es wieder soweit: Die lang erwartete Theatersaison im Kutenholzer Heimathaus beginnt wieder. Der allgemeine Vorverkauf findet am Sonntag, 4.

Januar , von 17 bis Einlass ist um Restkarten gibt es im Kaufhaus Lange. Mit Blick auf den Neuanfang in der Schule verabschiedeten sich die Kinder, ebenso wie ihre Eltern, mit einem lachenden und einem weinenden Auge.

Am Montag, Dezember Nordmanntannen am Nord-West-Ring zw. Rettungswache u. Bei warmem Kakao, selbst gebackenen Kuchen und Muffins klang der Nachmittag harmonisch aus.

Februar Am Donnerstag, Dezember , ab April 8. Mai 5. Juni 3. Juli Juli 7. Okt kt. Das Vereinsblatt verlost am Donnerstag, Um das eine oder andere Weihnachtspfund zum neuen Jahr gleich wieder loszuwerden, gibt es am Januar den Heeslinger Fitness-Funtag.

Insgesamt zehn Kurse in sechs Stunden werden am Gegen 17 Uhr erlangten alle heil und unversehrt das Hotel. Der Zeitplan war straff. Nach einer kurzen Erholungspause stand bereits am ersten Angebote zum Fest: Zwischen Weihnachten und Neujahr geschlossen!

Dezember Ab dem 2. Extra-Tag Jeden Freitag unsere leckere Verkostung. Angebote gelten, solange der Vorrat reicht. Dezember sowie am 5. Januar geschlossen!

Das Fazit aller Teilnehmer stand am Abend des fest: Es war eine tolle, erlebnisreiche Saisonabschlussfahrt.

Juni statt. Das Training in dieser Gruppe wird am Freitag, 6. Februar, um Brazil - World Team. Army - Copy Download: Mysteries and Thrillers.

Download: kiyotaino. Download: Top Film. Julie Newmar, Download: Kevin James. Download: Vladimir Kolev. Download: June Download: Eps4 The Putin Interviews Download: Odysseus - Macht.

Fifa Download: Lachlan J. Aleksej Glysin Legendarnye Pesni Download: gotzone Download: Le Journal de Mickey — 20 juin Download: Regarder.

Download: Witchblade nicht Anime. Download: Street Football. Conspiracy Download: P. Alive HD????? Download: Disneys Classic Cartoon. Download: Watch movie.

Brochure Magazine Download: Alain Choquet. Download: J. Download: The Messengers. Baixar The Walking Dead 7? Temporada via Torrent Download: 2x02 Get Shorty.

Pandemic Download: pompom Download: Novelas Querer Sin Limites 1x Download: a24 movies. Download: Watch American Animals free streaming.

Addison prim. Pankreas exokr. Wahl tis g om di S. Pankreas exo. Bei Remission kann die Konzentration bis unter die Nachweisgrenze abfallen.

SclAk, auch TopoisomeraseAk genannt. Positive ANA-Ergebnisse sollten z. Vorgehen bei V. Kollagenose 1. ANA, falls positiv: 2.

Nach bisherigen der Befund innerhalb von 2 Wochen kontrolliert werden. Viele Zeckenstiche bleiben unbemerkt.

T auch arteriellen Thromboseneigung. Die Erkrankung tritt isoliert oder im Zusammenhang mit anderen Autoimmunerkrankungen auf, insbesondere dem systemischen Lupus erythematodes aber auch bei M.

Nachweis sollte bei mindestens 2 Untersuchungen im Abstand von 12 Wochen positiv sein. Klinische Symptome bzw. Bei Infektionen nachgewiesene Cardiolipin-Ak sind meist niedrig konzentriert.

Falsch positive Ergebnisse treten seltener auf als bei den Cardiolipin-Ak. Die Infektion mit C. Reaktive Arthritis und M.

Eine Infektion mit C. Therapie Antibiotika der Wahl gegen C. Therapiedauer: mindestens 14 Tage Screening auf genitale C.

Das Screening sollte auch im Zusammenhang mit einem Schwangerschaftsabbruch angeboten werden. Anforderung und Material Erregernachweise C.

Bevorzugt 1. Bei einer C. Clostridium spp. Cephalosporine, Penicilline und Lincosamide Clinda- Yersinia spp.

Coli u. Coli, insb. Toxin , Clostridium spp. Infektion inkl. Darmkeine u. Proteus spp. Crohn, Ileumresektion Exokr.

Toxin , Clostridien inkl. Toxine , 3 x Stuhl Vibrio spp. TSH basal, ggf. Weitere Parameter Auto-Ak gg.

Insulinom Weblinks www. Das therapeutische Vorgehen kann nicht darauf ausgerichtet werden. Findet sich in der Regel bei einer bereits vorhandenen Dermatose oder Verletzung.

Es wird nur von phageninfizierten Corynebakterien gebildet. Differentialdiagnose Infektionen des oberen Gastrointestinal- bzw.

Epidemiologie In Westeuropa tritt die Erkrankung sehr selten auf. Sekreten oder Wunden nachweisbar ist. Ohne Behandlung zwei bis mehr als vier Wochen.

Bei Antibiotikatherapie zwei Labordiagnostik bis vier Tage. Pseudomembranen im hinteren Gaumenbereich, auf den Tonsillen Tonsillendiphtherie sowie im Pharynx.

Schmerzhafte Schwellung der regionalen Lymphknoten. Hypertoxische Diphtherie Maligne Verlaufsform mit letalem Ausgang.

Dabei entsprechen 3 cm Haar einem Untersuchungszeitraum von ca. Im Serum sind Nachweisempfindlichkeit und Nachweisbarkeitsdauer der Drogen schlechter, da die Substanzen in niedrigen Konzentrationen vorliegen.

Vor Einsendung anderen Materials z. Abbau pro h bis 0,2 Promille Nachweisbar i. Urin ca. Secobarbital Wochen lang wirkende: z. Phenobarbital klassische Benzodiazepine etwa 3 Tage nach therap.

Im Gruppentest werden u. Abusus reduz. Industrie verwandt. Keine illegale Substanz, Selbstkontrolle der Industrie bzgl.

Diazepam Buprenorphin SubutexR Cannabinoide z. Abusus Phencyclidin Im Gruppentest werden auch erfasst: Flunitrazepam z.

RohypnolR , evtl. Bestandteil von K. Der Nachweis umfasst Methadon und seine Metabolite. Remedacen , Monoacetylmorphin ein Metabolit des Heroins und Morphin.

In Deutschland wenig verbreitet. In einem etwas langsameren Schritt erfolgt die Metabolisierung zu Morphin.

Einnahme von morphinhaltigen Substanzen V. Heroin neben Dihydrocodein z. Bei positivem Opiatbefund ist in solch einem Fall von einem Beigebrauch von Opiaten z.

Heroin, Codein o. Cannabinoide des Haschisch und Marihuana nachgewiesen. Verdacht auf gelegentlichen Konsum. Einteilung 1.

Klassischer Speichereisenmangel mit erniedrigtem Ferritin u. Schweregrad Ferritin Transferrins. Vorkommen u.

Reaktionszeit: Wochen. Ferritin ist der Eisenbestimmung als orientierende Untersuchung zum Eisenstoffwechsel vorzuziehen.

Die Ferritin-Verminderung ist immer ein Hinweis auf Eisenmangel. Verlaufsparameter bei Dialysepatienten unter Erythropoetin-Therapie.

Die Eisenspiegel-Schwankungen gehen in die Berechnung ein. Transferrin Eisen-Transportprotein.

Differentialdiagnostisch sollten ggf. Persistiert lebenslang. Auftreten nach ca. Lebenslange Persistenz. Positiv bei akuten Infektionen, chronisch aktiven Infektionen oder als Zeichen einer Reaktivierung.

Es wird angenommen, dass CagA als bakterielles Onkoprotein direkt an der Tumorentstehung beteiligt ist.

Vor Therapiebeginn wird ein eindeutiger Helicobacter pylori-Nachweis gefordert. Zur Resistenztestung nach 2x Therapieversagen obligat, nach 1x Therapieversagen empfohlen.

CO2 13 diffundiert ins Blut und wird in der Atemluft gemessen. Nicht zur Therapiekontrolle geeignet.

Vereinzelt wird langsames Absinken beobachtet. Ein Wiederanstieg ist Hinweis auf Reinfektion. Nach erfolgreicher Therapie kommt es schon nach 6 Wochen zum Ak-Abfall.

Jahr mind. Labortests z. Quantitatives HBsAg kann unter Therapie hilfreich sein. Labortests alle 3 Monate bzw. Monat z.

Klinisch-chemische Basistests V. Lebererkrankung V. Ein positiver Befund sollte durch die Einsendung einer 2. Unspezifisch d. Durch die Einbeziehung des pAg in die Teste der 4.

Unter optimaler Therapie sollte nach Monaten die Viruslast unter die Nachweisgrenze ca. Sinnvoll bei Therapieversagen, signifikantem Anstieg der Viruslast unter Therapie sowie vor Therapie bei Patienten, die vorher mit anderen Regimes behandelt wurden.

Stand 01 Nr. Testosteron ges. Pharmaka, Stress etc. Amenorrhoe US, i. Umwandlung in Chylomikronen-Remnants, Abbau in der Leber.

Funktion: Transport exogener TG. Synthese in der Leber.

Cell Rep. Epub Dec 3. Anticancer Res. View this publication in the PUBMED database Retrospective assessment of quality of life and treatment outcome in this web page with Hodgkin's disease from to Hum Pathol. Nat Med. View this publication in the PUBMED database Complications of 5-azacytidine: Three cases of severe ischemic colitis in click patients with myelodysplastic syndrome.

Jäger Guide 7.0 Video

Int J Mol Sci. Fiegl M, Greil R. View this publication in the PUBMED database Nilotinib as frontline visit web page second-line therapy in chronic myeloid leukemia: open questions. View this publication in the JГ¤ger guide 7.0 database Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma. Einfach beide gönnen und selbst spielen. Epub Apr 8. View this publication in the Https://forrestfruits.se/filme-stream-kinox/kabel-doku-mediathek.php database Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy. Hodgkin's disease. View this publication in the PUBMED database [Expert recommendations on the rationale for second-line therapy for non-small cell bronchial neoplasms]. View this publication in the PUBMED database Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic deutsch frasier stream. View this publication in the PUBMED database Systemic effect of catumaxomab in a patient read article metastasized visit web page cancer: a case report. View this publication in the PUBMED database Maintaining bone density in patients undergoing treatment for breast cancer: is there an adjuvant benefit?

So richtig harmonierten sie nicht zusammen. Klaus Wiegers glich in seinem ersten Einzel gegen Werner Ritter aus. Im zweiten Einzel spielte Christian Rathjen wieder konzentriert und konnte den letzten Punkt erzielen.

Uwe Eimann konnte hingegen nur einen Punkt erzielen. In Bestbesetzung schlugen sie auf. Gut sind sie in das Punktspiel gestartet, denn zwei Doppel wurden gewonnen.

Er mobilisierte nochmal alles und ging als Sieger vom Tisch. Dass er das Spiel noch verlor, war mehr als Pech. SG Wiedau II 9 0 2.

Germania Hetzwege II 9 7 5. TuS Tiste II 9 9: 9 6. TuS Elsdorf II 9 6: 12 9. SV Jeersdorf 8 1: 15 Herren, 3. Ober Ochtenhausen II 9 5. SG Unterstedt 8 1 2.

TuS Mulmshorn 8 8: 8 7. II 8 5: 11 8. TV Hassendorf 9 5. TuS Hellwege 9 6. SV Jeersdorf II 9 8. FC Hesedorf IV 9 9.

II 9 Rotenburger SC 10 2. TuS Tarmstedt 9 3. TuS Zeven II 10 4. MTV Gyhum 10 5. MTV Wohnste 10 6. FC Hesedorf 10 7. TuS Alfstedt 8 8.

TuS Alfstedt II 8 SV Ippensen 8 TSV Gnarrenburg II 9 0 3 5 5 8 8: 12 7: 9 6: 14 2: 14 2: 14 0: 18 Mit Punkten geht der TuS jetzt in eine kurze Winterpause, bevor es am Die Puppenspielerin trat zum wiederholten Mal in der Turnhalle auf.

Viel zu schnell verging die Zeit. Dezember, und am Mittwoch, Dezember geschlossen bleiben. Zwischen Weihnachten und Neujahr, am Dezember, sowie ab Freitag, 2.

OG, gute Wohnlage, ca. DG, Terrasse u. Hanstedt: Single-Whg. Wanne ca. Auch Roberto Lutz setzte sich durch und das Spiel stand Gasheizung: Bedarfsausw.

Preis: VB Mehr Service. Weniger Preis. Experten schlagen jetzt Alarm. Immer mehr Kinder leiden unter einem teils extremen Schlafdefizit.

Nach einer Untersuchung des Kultusministeriums bekommen japanische Kinder im internationalen Vergleich am wenigsten Schlaf ab. Derzeit sammelt die Gruppe per Crowdfunding Geld ein, um eine App entwickeln zu lassen.

Viele von ihnen seien sehr ehrgeizig. Die Kinder haben damit praktisch einen Lebensstil wie ihre Eltern. Ihr sei vor allem wichtig, dass die Schoten auch wirklich aus New Mexico stammten, sagt die Kellnerin.

Im Sommer kaufen wir immer ganz viel frisch ein und lassen das dann trocknen, so haben wir sie das ganze Jahr.

Wurden sie noch auf rund Quadratkilometern angebaut, waren es im vergangenen Jahr nur noch rund Selbst Kalifornien produziert inzwischen bereits mehr Schoten als New Mexico.

Insgesamt sind bereits 82 Prozent der von Amerikanern ver- zehrten Chilis importiert. Auch ein Schutzgesetz des Parlaments des Bundesstaates soll dabei helfen.

Das klingt nach Verzicht und knurrendem Magen. Rohkost-Gerichte finden sich mittlerweile sogar auf der Speisekarte einiger Restaurants. Er wisse, dass auch diese Methode problematisch sei.

Sie stellte spezielle Kameras auf und legte Hundefutter aus, wo der Mischling zuletzt gesichtet worden war.

Februar ist es wieder soweit: Die lang erwartete Theatersaison im Kutenholzer Heimathaus beginnt wieder. Der allgemeine Vorverkauf findet am Sonntag, 4.

Januar , von 17 bis Einlass ist um Restkarten gibt es im Kaufhaus Lange. Mit Blick auf den Neuanfang in der Schule verabschiedeten sich die Kinder, ebenso wie ihre Eltern, mit einem lachenden und einem weinenden Auge.

Am Montag, Dezember Nordmanntannen am Nord-West-Ring zw. Rettungswache u. Bei warmem Kakao, selbst gebackenen Kuchen und Muffins klang der Nachmittag harmonisch aus.

Februar Am Donnerstag, Dezember , ab April 8. Mai 5. Juni 3. Juli Juli 7. Okt kt. Das Vereinsblatt verlost am Donnerstag, Um das eine oder andere Weihnachtspfund zum neuen Jahr gleich wieder loszuwerden, gibt es am Januar den Heeslinger Fitness-Funtag.

Insgesamt zehn Kurse in sechs Stunden werden am Gegen 17 Uhr erlangten alle heil und unversehrt das Hotel. Der Zeitplan war straff.

Nach einer kurzen Erholungspause stand bereits am ersten Angebote zum Fest: Zwischen Weihnachten und Neujahr geschlossen!

Dezember Ab dem 2. Extra-Tag Jeden Freitag unsere leckere Verkostung. Angebote gelten, solange der Vorrat reicht. Dezember sowie am 5. Januar geschlossen!

Diazepam Buprenorphin SubutexR Cannabinoide z. Abusus Phencyclidin Im Gruppentest werden auch erfasst: Flunitrazepam z.

RohypnolR , evtl. Bestandteil von K. Der Nachweis umfasst Methadon und seine Metabolite. Remedacen , Monoacetylmorphin ein Metabolit des Heroins und Morphin.

In Deutschland wenig verbreitet. In einem etwas langsameren Schritt erfolgt die Metabolisierung zu Morphin. Einnahme von morphinhaltigen Substanzen V.

Heroin neben Dihydrocodein z. Bei positivem Opiatbefund ist in solch einem Fall von einem Beigebrauch von Opiaten z.

Heroin, Codein o. Cannabinoide des Haschisch und Marihuana nachgewiesen. Verdacht auf gelegentlichen Konsum.

Einteilung 1. Klassischer Speichereisenmangel mit erniedrigtem Ferritin u. Schweregrad Ferritin Transferrins. Vorkommen u.

Reaktionszeit: Wochen. Ferritin ist der Eisenbestimmung als orientierende Untersuchung zum Eisenstoffwechsel vorzuziehen. Die Ferritin-Verminderung ist immer ein Hinweis auf Eisenmangel.

Verlaufsparameter bei Dialysepatienten unter Erythropoetin-Therapie. Die Eisenspiegel-Schwankungen gehen in die Berechnung ein.

Transferrin Eisen-Transportprotein. Differentialdiagnostisch sollten ggf. Persistiert lebenslang.

Auftreten nach ca. Lebenslange Persistenz. Positiv bei akuten Infektionen, chronisch aktiven Infektionen oder als Zeichen einer Reaktivierung.

Es wird angenommen, dass CagA als bakterielles Onkoprotein direkt an der Tumorentstehung beteiligt ist.

Vor Therapiebeginn wird ein eindeutiger Helicobacter pylori-Nachweis gefordert. Zur Resistenztestung nach 2x Therapieversagen obligat, nach 1x Therapieversagen empfohlen.

CO2 13 diffundiert ins Blut und wird in der Atemluft gemessen. Nicht zur Therapiekontrolle geeignet. Vereinzelt wird langsames Absinken beobachtet.

Ein Wiederanstieg ist Hinweis auf Reinfektion. Nach erfolgreicher Therapie kommt es schon nach 6 Wochen zum Ak-Abfall.

Jahr mind. Labortests z. Quantitatives HBsAg kann unter Therapie hilfreich sein. Labortests alle 3 Monate bzw. Monat z. Klinisch-chemische Basistests V.

Lebererkrankung V. Ein positiver Befund sollte durch die Einsendung einer 2. Unspezifisch d. Durch die Einbeziehung des pAg in die Teste der 4.

Unter optimaler Therapie sollte nach Monaten die Viruslast unter die Nachweisgrenze ca. Sinnvoll bei Therapieversagen, signifikantem Anstieg der Viruslast unter Therapie sowie vor Therapie bei Patienten, die vorher mit anderen Regimes behandelt wurden.

Stand 01 Nr. Testosteron ges. Pharmaka, Stress etc. Amenorrhoe US, i. Umwandlung in Chylomikronen-Remnants, Abbau in der Leber. Funktion: Transport exogener TG.

Synthese in der Leber. Funktion: Transport der endogen aus Kohlenhydraten synthetisierten Triglyceride in die Peripherie.

Lipidaustausch zwischen peripheren Geweben und der Leber sowie mit anderen Lipoproteinen im Plasma. Basisdiagnostik II.

Das individuelle Risiko kann mit Hilfe von Scores ermittelt werden siehe www. Die Konzentration ist genetisch determiniert und therapeutisch kaum beeinflussbar.

Therapeutisch durch Vitaminsubstitution gut beeinflussbar. Adiponektin Im Fettgewebe synthetisiertes so genanntes Adipokin, wirkt als physiologischer Insulinsensitizer.

Beeinflussbar durch Gabe von LArginin. Beide Spezies B. Achtung, keine Tupfer mit Gel verwenden! Bordetella spp. Woche nach Erkrankungsbeginn oder nach Impfung gebildet.

Bei klinischem V. Aufgrund der engen Verwandtschaft von B. Bei Patienten mit fehlender Impfdokumentation sollte vor dem Hintergrund eines begrenzten Impfschutzes in erster Linie eine Auffrischungsimpfung erfolgen, sofern keine Kontraindikationen bestehen.

Mittel der ersten Wahl sind Makrolide z. Es wird von einem autonom proliferierenden Klon eines B-Lymphozyten oder einer Plasmazelle gebildet.

In der Immunfixation kann es dann definitiv nachgewiesen und nach Typ differenziert werden. Bence-Jones-Plasmozytom gebildet werden.

Selten werden nur Schwerketten synthetisiert. Bei V. Daher korreliert die Serumkonzentration mit dem Lymphozytenumsatz.

B2M ist ein wichtiger Tumormarker, sofern bei normaler Nierenfunktion keine interkurrente Infektion vorliegt. Erfassung noch reversibler Glomerulopathien, z.

Zur Verlaufskontrolle durch quantitative Urinprotein-Bestimmung von z. Diabetes, Hypertonie etc. Anforderung und Material Parameter Albumin quant.

Morgenurin Transferrin im Urin 20 ml 2. Erkrankung Pyelonephritis bakteriell interstitielle Nephritis, Plasmozytom toxisch Blei, Cadmium etc.

Medikamente Analgetika, Aminoglykoside, Methicillin,Cephalosporine etc. Syndrom Systemerkrankung SLE etc. Epidemiologie Einziges Erregerreservoir ist der Mensch.

Schwangerschaftswoche ausgesprochen. Die Durchseuchungsraten nehmen proportional zum Alter zu und betragen im Erwachsenenalter ca.

Keine Schleimhautbeteiligung! Laborinformation Therapie Unkomplizierte Infektionen erfordern keine Therapie, ggf.

Infizierbare fetale Erythroblasten bilden sich ab der Embryopathien Fehlbildungen werden nicht beobachtet. Bei gesicherter Infektion der Schwangeren typische Klinik u.

Bleibt der Befund bis 12 Wochen nach der Infektion der Mutter regelrecht, so ist mit fetalen Komplikation nicht zu rechnen.

Amoxicillin oral Ampicillin oral, i. Mezlocillin i. Piperacillin i. Flucloxacillin oral, i. G1: Cefaclor oral Cefazolin i.

G2: Cefuroxim oral. Cefotiam i. G3: Cefpodoxim oral Cefixim oral G3a: Cefotaxim i. Ceftriaxon i. G3b: Ceftazidim i. Imipenem i. Meropenem i.

Ertapenem i. Paromomycin oral, keine system. Wirkung Kanamycin lokal: Augen Doxycyclin oral, i. Roxithromycin oral Azithromycin oral, i.

Rifaximin oral, keine systemische Wirkung Trimethoprim-Sulfamethoxazol oral, i. Metronidazol oral, i. Vancomycin oral, i.

Linezolid oral, i. Tigecyclin i. Punktion M. Stand 07 Nr. IBM MobileFirst is designed to support any type of systems of record, rather than favoring one system or technology in particular, such as SAP systems.

Excessive SAP customizations result in significant problems with future platform upgrades.

Custom development of mobile applications for SAP is fully enabled with the IBM MobileFirst Platform, which should be the standard enterprise platform for any custom mobile development.

Project experiences show that the cost of custom development for SAP on IBM MobileFirst is significantly lower compared with other types of custom application development, for example, full-featured web-based business applications.

IBM MobileFirst not only provides a best-in-class mobile development platform, but it includes a rich set of fully integrated enterprise capabilities for security, lifecycle management, mobile analytics, user experience feedback, and many others.

Portal IBM WebSphere Portal is the market-leading platform for delivering relevant, personal, and engaging user experiences to customers, partners, and employees.

By integrating best-in-class business applications from SAP, with leading digital experiences from IBM, organizations can compete more effectively and enhance the productivity of their employees.

Different users and use cases are best served by different types of integration. Create a new user experience to access SAP services.

The use cases for the interactions of enterprise users with SAP can be categorized into casual and detailed.

The majority of employees and possibly customers will likely make casual use of SAP systems. These users need occasional access to information that originates in the SAP system.

They need the information in the context of what they are doing, and do not need to know that an SAP system is involved.

Casual use cases might involve a sales person looking up customer information or pricing. Casual use cases are often best addressed by a new or simplified component that integrates with SAP at a service level.

This integration option is particularly well-suited for an externally facing portal, because it can provide UI differentiation with a new user experience, one which is different from other companies that also use SAP systems.

Detailed use cases typically involve more than just simple access to SAP content. An example of a detailed use case is a sales person creating a new customer opportunity in the SAP customer relationship management CRM system.

SAP provides a ready-to-use user experience that has been refined to meet the needs of such detailed scenarios. It generates a rich web experience for working with SAP data based on an extensive catalog of predefined UI templates.

Master data is usually non-transactional. MDM solves the problem of multiple copies and sources of the same master data in the enterprise, and provides trusted and timely master data to business processes.

MDM also solves the problem of multiple and inconsistent source systems for master data, by managing these business-critical information assets consistently with the highest degree of data quality.

In addition, MDM has to provide the trusted master data in a timely manner, either batch-oriented or in near real-time, to all relevant business processes.

Without MDM, clients are often tempted to extend master data definitions within the SAP solution to suit various needs of a particular business scenario.

With an MDM solution in place, the MDM platform is designed to incorporate constantly evolving master data definitions, therefore avoiding the need to customize the SAP application beyond the intended scope of the solution.

The master data definition for customer in SAP CRM should not contain any more attributes than those needed to support the sales and support processes.

A robust MDM solution can be much more efficient as a high-transaction, reliable system of reference for master data.

As an example, consider a web commerce application that needs to display the basic customer information. Without MDM, there is no assurance that duplicates will be properly handled, or organizational data quality standards will be adhered to, when new master data is entered.

This is particularly important for SAP applications, because it is often difficult to completely remove master data records from SAP after they are entered.

This is especially true if operational data exists that references the master data, for example orders, invoices, and so on.

The MDM system manages master data entities, such as customer, supplier, product, and employee, providing master data with the highest degree of quality to all consumers.

In typical implementations, SAP applications only hold a copy of the master data entities the dotted lines around the master data entities in Figure , which is managed by the MDM system.

The MDM platform incorporates data governance and stewardship. This covers both transactional and batch interactions. In some cases, an MDM refactoring project might need to precede large-scale SAP adoption, or run in parallel to it, but in either case it must receive adequate focus in the enterprise.

This content, which is typically referred to as unstructured content, is a permanent component in all business workflows.

It supports and documents them in an auditable manner. All of this information is essential to support the decision processes of all SAP users.

This information must be maintained throughout its lifecycle to manage its growth and ensure legal compliance. For example, from its inception captured in paper form, converted to electronic form, throughout its way through the system with annotations, approvals, and so on, up to its disposal.

Frequently, the SAP infrastructure is not the only one that creates, operates on, and manages such information.

Other systems often exist in the organization that originate documents of a similar nature, and of similar importance to the business decision-making process.

Consequently, information integration between the SAP and non-SAP landscapes, to provide a unified view on all business relevant information, is vital for the operation of the enterprise.

In addition, IBM ECM offers a spectrum of crucial extended and extendable capabilities to perform content discovery, content analytics, and case management.

Clients often consider the cost of deploying ERP systems to be a part of the cost of doing business. Alternatively, business analytics solutions excel at enabling better business decisions to manage and drive business performance by providing complete visibility and fast insights into the business.

Some organizations, where users need to perform swift analysis of data from SAP solutions, require a faster-performing business intelligence solution.

The next-generation business analytic solutions from IBM help organizations of all sizes make sense of information in the context of their business.

Organizations can uncover insights more quickly and more easily from all types of data, even big data, and on multiple platforms and devices.

In a heterogeneous IT landscape, SAP systems are an important source, but not the only source, of information for contextual enterprise analytics.

SAP data has to be combined with business data from other enterprise systems to enable the contextual enterprise.

In addition, using IBM Cognos software and SAP applications together can help minimize the number of tools and duplicate content that organizations must maintain, streamline training requirements, and significantly reduce IT backlogs.

TM1 enables users to analyze data and create models, including profitability models, to reflect a constantly evolving business environment.

In addition, the integrated scorecards and strategy management capabilities help organizations monitor performance metrics, and align resources and initiatives with corporate objectives and market events.

TM1 features memory-based, multi-dimensional cube architecture. And with multiple memory-based cubes, data is more rapidly searched, modified, and restructured than with a single-cube, disk-based structure.

Predictive analytics helps organizations to use all available data and predict with confidence what will happen next, so that you can make better decisions and improve business outcomes.

These solutions meet the specific needs of different users and skill levels, from beginners to experienced analysts. All deeper analytics and all analytics at an enterprise level should be based on the EDW.

Deeply integrate with SOA data. Provide near real-time SAP data replication into analytics solutions. Provide more structured data extraction and cleansing capabilities.

The IBM InfoSphere Information Server is a key component that encapsulates best-in-class integration tools to collect metadata, and to manipulate or assess data before integration with consumer BA applications.

Traditional approaches to SAP development, integration, management, and delivery rely largely on manual processes. This approach is error-prone and time-consuming, delaying the response to business needs and IT change requests.

Silos of processes, projects, people, and tools can make it difficult to gain a clear view of systems and processes, and to align business and IT requirements.

For organizations looking to improve the value delivered by SAP solutions, a more unified and flexible approach is needed.

IBM believes that the key to addressing these challenges lies in the IBM DevOps solution, a contraction of development and operations, the two teams that deliver the core IT services in an organization.

By bringing these teams closer together, and applying agile principles across the entire SAP delivery lifecycle, the IBM DevOps solution promotes continuous innovation, feedback, and improvement.

This approach enables you to accomplish the following goals: Help development and operations teams boost productivity.

Improve the value delivered to users. Accelerate delivery. Reduce the cost and effort of IT change. IBM has the tools and technology to achieve continuous delivery, and to reduce the cost and risk of managing changes to the SAP landscape.

Figure on page 35 shows how the IBM DevOps solution complements and extends SAP, using a set of pre-built and pre-integrated components to provide an effective lifecycle management solution in a heterogeneous enterprise.

IBM requirements management solutions enable you to effectively manage any form of business requirements definitions. However, all of the SAP Blueprint content is managed in IBM requirements management as structured data, which provides further structure and decomposition to SAP-controlled Blueprint business process hierarchy.

This approach provides more structured, traceable, and integrated management of the actual contents of SAP Blueprint when compared to the traditional all-SAP approach, whereby such requirements are managed manually as basic document attachments.

Overall, the guideline from this reference architecture is to use SAP Solution Manager to capture business process hierarchy for SAP Blueprint, mirror it in IBM requirements management, and use the latter to manage actual requirements contents as structured data.

With the IBM solution for project planning and execution, SAP project teams can use a single tool for project and iterations plans, work item tracking, deliverable activity management, and release planning.

This approach enables teams to plan and run projects based on end-to-end business processes, and to coordinate all changes and release deliveries across the different applications and systems.

IBM Rational Team Concert is also used as the collaborative project hub to track all work, control project governance, and identify gaps in work items.

Change and defect management Change management is a key component in the solution lifecycle governance. Effective change request management requires a common information repository that all team members can access.

In this reference architecture, IBM Rational Team Concert is used to define and govern changes throughout the project lifecycle.

Complex changes can be delivered to all affected SAP and non-SAP applications and middleware systems in a synchronized fashion.

Defect management is typically considered a variation of change request management. For example, a specific defect can be forwarded to the SAP Service desk.

Quality management Quality management consists of three main functional areas: Test planning Test execution Test reporting In addition, defect management is typically viewed as an extension to quality management, although within the context of application lifecycle management it is usually captured as a specific variation of change request management.

This approach enables you to automatically map elements in the SAP business Blueprint to test plans and test cases.

The Blueprint becomes a general business-focused container for the overall test architecture. Agile for SAP Agile software development and delivery is mainstream for custom application development.

It is increasingly being used to successfully develop and deliver packaged applications, including SAP applications and changes.

The core of this solution is IBM Rational Team Concert, a market-leading agile project planning, change, defect, and delivery management solution.

Enable better decisions based on real-time, transparent visibility into SAP Agile delivery and maintenance projects.

Accelerate agile adoption and results using pre-configured and customizable agile or others method definition and automated enactment.

An inability to continuously deploy can negate the investment that organizations make in developing and implementing change into business processes and integrations.

Traditional approaches to SAP deployment rely largely on manual processes and spreadsheet management. These approaches can be error-prone and time-consuming, delaying the response to business needs and IT change requests.

SAP application landscapes are most often composed of many different applications that are interdependent and can often involve both SAP and non-SAP applications and components.

Specifically, it provides the following capabilities: Plan, coordinate, orchestrate, and manage releases of integrated application deployments.

Automate the deployment of required non-SAP configured middleware. IBM Reference Architecture for SAP 37 These capabilities lead to quicker releases, improved communications, and lower risk associated with the software releases.

Enterprise planning for SAP Successful IT transformation investments in SAP establish an enterprise architecture to provide organizations with a big picture, and the framework to select the best overall route for SAP adoption in a heterogeneous enterprise.

By effectively incorporating SAP software into the enterprise architecture, organizations gain better insight into their overall technology plans.

With an enterprise architecture in place, organizations can ensure that the SAP business model as defined is the business model that they implement, and can guide SAP investments to run outcomes that support their corporate strategy.

IBM Rational System Architect is an enterprise architecture tool that enables organizations to effectively analyze and plan their business and technology architecture.

The purpose of this chapter is to provide an introduction to enterprise integration services, and explain how the various applications are efficiently integrated.

Enterprise integration services for SAP include both near real-time transactional and batch-oriented integration techniques. For most SAP solutions, integration activities can be divided into two major categories: Initial data load also referred to as conversion in many SAP projects Ongoing integration also referred to as interfaces in SAP projects As the name suggests, initial data load involves the one-time activities required to move large volumes of data from existing systems into the new system in this case, SAP and related application components before going live.

The ongoing integration involves all of the interfaces between existing systems and the new system performed on a regular basis after the new system is live.

The ongoing integration encompasses a wide range of integration requirements and approaches: Batch versus transactional, synchronous versus asynchronous, service-oriented versus message-oriented, and so on.

This chapter provides a coherent architectural blueprint for both ongoing integration with SAP applications and initial data load into SAP applications.

This chapter includes the following topics: 3. Therefore, to integrate with SAP applications, you must first understand which interfaces SAP applications offer for integration.

The figure shows that the Web Application Server run time is the common runtime infrastructure for the SAP applications. Older versions of the Web Application Server, for example versions 6.

Newer versions, starting with version 7. All of these interfaces operate on logical models at the application level, because a key design decision by SAP has been to decouple the applications from the underlying databases, such as IBM DB2, Oracle, and so on.

For many years, IBM has provided SAP certified connectivity using all of the integration mechanisms with SAP applications described in this section, enabling both transactional and batch integrations.

The IDDs identified during the blueprint phase of the SAP methodology do not make a distinction between the different types of interactions, such as transactional versus batch.

IBM software provides different technologies to address the different integration requirements. The goal of the architecture blueprint described in this chapter is to provide a coherent coverage for both transactional and batch integration aspects, and to provide guidelines for selecting appropriate IBM integration middleware based on SAP integration requirements.

In some cases, the technologies include pre-built integration modules that can be configured for a particular environment, and used without the need for any custom development.

However, customizations made within the SAP applications limit the extent to which the pre-built integration capabilities can be used without modification.

Additionally, many of the SAP integration technologies require custom development to provide the integration logic and do not provide any special capabilities with regard to SAP application components.

Chapter 3. Enterprise integration services for SAP 41 3. During the transition, the new functionality is not yet fully rolled out.

As a result, there are two types of integration requirements for transition architecture: Non-SAP applications that are non-strategic in the long term, but must be integrated with SAP applications and remain operational until the new system can fully assume the business functions Non-SAP applications providing strategic functionality that will not be incorporated into the SAP solution, and that need to be permanently integrated with the new system Strategic non-SAP applications should be integrated with SAP applications according to established standards and leading practices.

Integration costs can be justified with longer-term benefits in maintenance cost reduction, flexibility, adherence to strategic objectives for the enterprise, and so on.

However, for those non-SAP applications that are expected to be decommissioned after the new system is in place, there is often little justification for making further investments.

Depending upon the status of the application, making additional changes might not even be possible. As a result, the approach to integrate non-strategic existing applications can require changes in either the application or the integration layer.

In this case, the least expensive integration approach overall should drive the changes. The integration of non-strategic applications is usually short-lived after the transition is completed.

Therefore, it is important to limit the expense and effort put into it. Loose coupling enables one component to be replaced with little to no effect on the other components.

It enables components to be reused by other consumers. It also isolates systems to improve resiliency and enable for components to be defined and developed independently.

It also increases the availability of tools that easily connect to the solution and provide support for development, monitoring, and testing.

As a practical point, when attempting to move two proprietary systems to a common format or approach, selecting an open, industry standard can often provide a neutral option that prevents the mine versus yours arguments.

The following sections provide guidance on how to classify the interfaces based on the integration requirements. The appropriate integration scenario and preferred integration patterns for those scenarios are identified.

Interface characteristics The first step in selecting an integration pattern is to identify the characteristics and requirements of the integration itself.

Many of the characteristics can be applied independently of each of the systems involved in the overall interaction, which causes variations within the patterns.

For example, the originator uses a one-way message exchange pattern, although the destination uses a request-response pattern.

Interaction style: Transactional or batch The first major division among the various interfaces is the interaction style: Does the interface represent a single business transaction and business object, or does it represent a collection of multiple business objects?

The answer to this question results in either a transactional or a batch integration style. Remember: The term transactional does not refer to requirements dealing with the transactional integrity of the interface.

Rather, it indicates that the interface represents a single business transaction. This identification should be made solely on the contents of the message, and not on other outside factors, such as the frequency of the interface or the planned transport.

The following examples help to identify the interaction style: A query object containing a set of attributes is submitted with a response that contains multiple results: Transactional.

A collection of existing customer numbers are sent to a customer translation service to return a collection of proper customer identifiers: Batch.

A message flow sends a business event containing the current message processing context to the event infrastructure in a fire-and-forget operation: Transactional.

Every five minutes, a business application is triggered to collect all of the changed records and send them to the destination system: Batch.

Message exchange pattern: Request-response or one-way The message exchange pattern identifies the interface as either request-response or one-way.

If the sender of the message expects an answer back from the request that was sent, regardless of the timing of the answer, it is a request-response exchange.

If a message is sent without a business response, it is one-way. Message response timing: Synchronous or asynchronous The response timing indicates whether the interaction is synchronous or asynchronous.

Generally, asynchronous interactions are preferred over synchronous interactions if an immediate response is not required, because it gives greater flexibility for managing the load.

Interaction effect: Read-only or change There are two options for the effect of the interaction: Read-only or change.

Change applies to interfaces that make changes to the back-end system. Read-only applies to interfaces that are simply running a query to read information.

Enterprise integration services for SAP 43 Message handling: Independent, grouping, or sequential Message handling refers to how to handle the messages as they arrive in the middleware software.

The messages are either independent of one another, part of a larger group, or require sequential handling: Message handling: Independent The most common and simplest situation for the message sources is independent processing: The messages are processed independently of one another as they arrive.

Message handling: Grouping Grouping means that the messages are part of a group, and processing cannot begin until all of the messages arrive and they can be processed together.

Message handling: Sequential Sequential processing indicates that the order of the message processing is dependent either on the order in which the messages arrive or on some sequencing information found within the messages.

Destination cardinality: Single or multiple Destination cardinality refers to the number of destination systems service providers that are involved in the interaction: A single system or multiple systems.

If the cardinality is multiple, there are several subcategories: Multiple destinations: Routing Although there can be multiple possible destinations, any particular message is sent to one and only one of the destinations, based on some set of business rules.

The business rules might evaluate the business elements within the message in addition to the timing and context of the operation. Multiple destinations: Aggregation In this case, all of the destinations are involved in the interface.

Each of the service providers is started independently, and the results are compiled together into a single response message.

Each of the destination systems has independently established business rules defining which messages they are interested in receiving. When the message is received, each of the rules is evaluated and the message is sent only to the matching destinations.

Multiple destinations: Sequential dependency For sequential dependency, there are multiple destinations that are dependent on one another in some way.

For example, a message is sent to System A and after a successful response has been received a message is sent to System B, then System C, and so on.

In some cases the response from one system is used to create the request for the next system. Each of the connectivity options varies in terms of availability and capabilities, and some options are preferred over others.

SAP connectivity Table is a summary of SAP end point connectivity options available for different interface styles.

SAP Enterprise Services should be evaluated for use whenever one is available for a particular business function.

The evaluation should be made based on how well the Enterprise Service matches the defined interface characteristics, and how well the Enterprise Service addresses the particular non-functional requirements.

However, the catalog of available services is rather limited, so the opportunity for using them might be small. Tip: If an SAP Enterprise Service for a particular business function is not available, it is not considered a good practice to create a custom web service directly within the SAP environment.

Instead, the services should be developed using best-in-class tools for developing and managing services.

This approach enables you to expose the SAP function through the enterprise service bus ESB in a standard manner across the enterprise.

RFC operations block the thread within the SAP systems while the operation is performed against other function modules and the database.

As a result, RFC should be used to perform transactional individual business operations and synchronous interactions with SAP systems. Business Application Programming Interface.

Advanced Business Application Programming. IBM ABAP Stage should be used in batch interfaces where data must be extracted from SAP and sent to non-SAP systems, and where ready-to-use operations are not already available in SAP to perform the data extraction, that is, situations where custom development would otherwise be required.

Intermediate Document. Within SAP systems, IDocs provide a particular hierarchical message format that can be posted to SAP asynchronously using standard RFC transports, including mechanisms for transaction management and queuing.

IDocs typically represent data of an SAP business object or array of business objects, for example, a purchase order. Additionally, two IDocs one inbound and one outbound can be used to implement asynchronous request-response message exchange patterns.

File system. In some rare cases, particularly when using custom existing SAP function modules, it is necessary to provide information to the SAP system from the file system.

HTTP-based web services are perhaps the simplest way to perform integration. Much of the work required to perform the integration using web services is provided by available tools.

By adopting additional web service standards, support can be added for other capabilities, such as security WS-Security , transactional integration WS-Transaction , and reliable messaging WS-RM.

HTTP-based web services are traditionally used in synchronous request-response or one-way interactions.

They can also be used in an asynchronous fashion using either Request with Callback or Request with Polling patterns. In the Request with Callback pattern, the response is sent by making a separate call from the service provider or ESB back to the service consumer.

In the Request with Polling approach, the response from the initial request is a ticket that identifies the request.

The consumer makes subsequent calls using the provided ticket to retrieve the response if it is available. RESTful Services. RESTful services are commonly used with mobile and Web 2.

These services are ideal for interfaces that operate in an asynchronous fashion, both batch and individual interaction styles.

Reliable File Transfer. RFT is the transport protocol for moving files around the infrastructure in a centrally controlled manner.

RFT can be deployed transparently to the source and destination systems. The systems deal with files on the local file system, and RFT does the work required to get the files where they need to go.

File Transfer Protocol. The connectivity information and the security certificates must be managed by each end point application.

Appropriate only in special situations, direct database interactions can be used in batch interfaces to retrieve or store large volumes of information.

The challenge with using direct database interactions is that it almost always requires detailed application logic within the middleware, particularly if the connection is made to the application's operational database as opposed to an information warehouse or staging tables.

Enterprise integration services for SAP 47 3. This section describes the most commonly used integration patterns.

Simple batch The simple batch integration pattern shown in Figure uses the batch capabilities of the ESB software, for example, IBM Integration Bus, to satisfy simple batch requirements.

Basic mediation requirements for the middleware, for example, transformation and basic field translation. Modestly-sized batch messages, for example, less than 25 megabytes MB.

Simple batch integration can have a single source or multiple sources, depending upon the nature of the data and the interface the dashed lines in Figure indicate optional components.

For example, either a single system provides a particular set of business data, or multiple systems do.

Similarly, simple batch integration can have a single destination or multiple destinations. However, for an interface to be considered simple batch, there should be no dependency between the sources and destinations.

Complex mediation requirements, for example, cleansing, staging, complex transformation, complex field translation. Large messages sizes greater than 25 MB.

As with simple batch integration, the cardinality of the sources and destinations is one-to-many for complex batch integration, meaning that either side can have multiple systems.

Unlike simple batch, complex batch can include dependencies between the various systems or the messages of a single system.

One-way transactional In this integration pattern, as shown in Figure , one or more service consumers send a one-way message that represents a single business transaction to the service provider.

Optionally, multiple service providers can be accommodated, assuming the logic follows either the routing or broadcast approach for multiple destinations.

Optionally, multiple service providers can be supported if the ESB selects one of the service providers and routes the message to the appropriate end point.

Enterprise integration services for SAP 49 Asynchronous transactional request-response If the interaction can be performed asynchronously, the asynchronous transactional request-response pattern shown in Figure should be used.

0 comments on Jäger guide 7.0

Hinterlasse eine Antwort

Deine E-Mail-Adresse wird nicht veröffentlicht. Erforderliche Felder sind markiert *

Nächste Seite »